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Periodic Paralysis News Desk

Resources for the Periodic Paralysis Community since 1995

Quality of Life Assistant

Glossary

Abortive Attack
Long-lasting period of weakness short of paralysis, often characterized by daily fluctuations. Abortive attacks can be so persistent that they can be confused with Permanent Muscle Weakness (PMW).
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Anaphylaxis / Anaphylactic shock
A severe allergic reaction.
Arrhythmia
Disturbance of heart rate and rhythm.
Bradycardia
An abnormally slow heart rate and pulse, less than 60 beats per minute
COPD
Chronic obstructive pulmonary disease. Group of diseases and conditions in which the lungs decline in their ability go exchange gasses
CVA
Cerebral vascular accident or stroke. Damage or blockage to the blood vessels of the brain resulting in a lack of blood supply to the brain.
EKG
Electrocardiogram (also called ECG).
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GERD
Gastroesophageal reflux disease.
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GI
Gastrointestinal.
GU
Genitourinary
HDL
High density Lipoproteins (“Good Cholesterol”)
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Hyperglycemia
Excess of sugar in the blood.
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Hyperlipidemia
High Cholesterol.
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Hypertension
High blood pressure.
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Hypoglycemia
Too little sugar in the blood
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Hypotension
low blood pressure
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IDDM or NIDDM
Insulin dependant Diabetes Mellitus (Type I Diabetes) or Non-insulin dependant Diabetes Mellitus (Type II Diabetes).
More information on Diabetes Mellitus
LDL
Low density lipoproteins (“Bad cholesterol”)
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Malignant Hyperthermia
A syndrome characterized by increase body metabolism and muscle rigidity that can result in death. It is triggered in susceptible individuals by commonly used genera anesthetics.
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Milliequivalent (mEq)
A system used to quantify electrolytes. Specifically, an equivalent is the amount of substance needed to combine with one mole (6.02×1023)of H+ ions or OH- ions. A milliequivalent is 1/1000 of an equivalent.
Conversion chart
NSAIDs
Non-steroidal anti-inflammatory drugs
OTC
Over the counter - Medication that does not require a script.
Palpitations
Heartbeats that are unusually strong, rapid or irregular enough to make a person aware of them. They are felt in the chest, throat, and neck and may be regular or irregular in nature.
Paralysis
Complete or partial loss of the ability to move a body part. Sensation in area may also be lost.
PMW
Permanent Muscle Weakness. Weakness caused by permanently flaccid muscle cells, most likely progressive in nature and occurring over decades.
Syncope
Loss of consciousness due to many causes. Most causes produce a dramatic fall in blood pressure, which leads to fainting.
Tachycardia
Rapid heart rate greater than 100 beats per minute.
Vacuoles/vacuolization
When a patient with some forms of PP (not all mutations or types - just some) has an episode, water leaves the blood and moves into the muscle fibre. Muscle fibres are long skinny cells, enclosed in a sheath (membrane). The water moves through the membrane and enters the muscle fibre, collecting in small fluid-filled bubbles up and down the length of the fibre. These bubbles are called vacoules (from the Latin word for empty). To begin with these bubbles of fluid empty out, collapse and disappear, but as we get older, or if we have particularly severe episodes, some of the "bubbles" remain in the muscle fibre. Over time they get filled with a granular material, so they are then semi-solid. Two or more small vacuoles can coalesce into one large one, and can shove aside and replace working muscle fibre. Eventually the ability of the muscle to function is compromised. Weakness produced by this process is called "permanent muscle weakness" or PMW.